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匆匆过客九龙山

古今多少事,都付笑谈中!

 
 
 

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2007年11月27日  

2007-11-27 09:38:52|  分类: 默认分类 |  标签: |举报 |字号 订阅

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                     利用人体皮肤细胞改造成类似胚胎干细胞的“万能细胞

       轰动世界的浙江诸暨留美博士俞君英所在科研机构发表的利用人体皮肤细胞改造成类似胚胎干细胞的“万能细胞的”文章。这是一项以非克隆技术培养人类干细胞的重大研究。有科学家认为:胚胎干细胞克隆技术研究可能就此走下历史舞台。美国白宫认为:这是一项在符合伦理道德的研究中取得的重大进展。

Induced Pluripotent Stem Cell Lines Derived from Human Somatic Cells
Junying Yu,1,2* Maxim A. Vodyanik,2 Kim Smuga-Otto,1,2 Jessica Antosiewicz-Bourget,1,2 Jennifer L.
Frane,1 Shulan Tian,3 Jeff Nie,3 Gudrun A. Jonsdottir,3 Victor Ruotti,3 Ron Stewart,3 Igor I. Slukvin,2,4 James
A. Thomson1,2,5*
1Genome Center of Wisconsin, Madison, WI 53706–1580, USA. 2Wisconsin National Primate Research Center, University of
Wisconsin-Madison, Madison, WI 53715–1299, USA. 3WiCell Research Institute, Madison, WI 53707–7365, USA.
4Department of Pathology and Laboratory Medicine, University of Wisconsin-Madison, Madison, WI 53706, USA. 5Department
of Anatomy, University of Wisconsin-Madison, Madison, WI 53706–1509, USA.
*To whom correspondence should be addressed. E-mail: jyu@primate.wisc.edu (J.Y.); thomson@primate.wisc.edu (J.A.T.)

Somatic cell nuclear transfer allows trans-acting factors
present in the mammalian oocyte to reprogram somatic
cell nuclei to an undifferentiated state. Here we show that
four factors (OCT4, SOX2, NANOG, and LIN28) are
sufficient to reprogram human somatic cells to
pluripotent stem cells that exhibit the essential
characteristics of embryonic stem cells. These human
induced pluripotent stem cells have normal karyotypes,
express telomerase activity, express cell surface markers
and genes that characterize human ES cells, and maintain
the developmental potential to differentiate into advanced
derivatives of all three primary germ layers. Such human
induced pluripotent cell lines should be useful in the
production of new disease models and in drug
development as well as application in transplantation
medicine once technical limitations (for example,
mutation through viral integration) are eliminated.

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